Tuesday, October 20, 2020

Female Women And Hysteria In The History Of Mental Illness

4. Middle Ages

After the fall of the Roman Empire, Greek-Roman medical culture had its new epicenter in Byzantium, where physicians inherited Galen’s science without making any significant innovations (the most famous was Paul of Aegina, 625-690 AD). Sometime before, Bishop Nestorius (381-451 approx.), who took refuge in the Middle East in an area between today's Iraq and Egypt, had brought with him his knowledge of classical science, contributing to the spread of Greek-Roman medicine in these areas.

The political events of the early Middle Ages caused a rupture between Christian Europe, with its auctoritas culture - in the hands of just a few scholars - and the Middle East of the Caliphs, where thanks to a climate of tolerance and cultural ferment, the texts of Hippocrates and Galen were translated and commented on in Arabic, becoming widespread and well-known [].

In this context, two great scientists carry out their work : the Persian Avicenna (980-1037) [,] and the Andalusian Jew Maimonides (1135-1204) []. Thanks to them, the legacy of Hippocrates and Galen is not only maintained, but spreads throughout Europe: the Reconquista of Spain (718-1492) and new contacts with the Near East bring important cultural exchanges, Avicenna’s Canon of Medicine and Galen’s Corpus are diffused along with the Latin translations ascribed to Gerard of Cremona (1114-1187), while Maimonides’ texts are disseminated in the Jewish world, along with other basic medical texts, thanks to translations by the Ibn Tibbon family (13-14th centuries). In particular, the medical schools of Salerno and Montpellier were vehiclesfor the dissemination of these works [].

This was how Hippocratic concepts of melancholia and hysteria spread in late-medieval Europe, and in informed circles these diseases were treated according to what we shall call the “scientific” vision. In particular, this advocated the use of melissa as a natural remedy nerve comforter (melissa was considered excellent even in cases of insomnia, epilepsy, melancholy, fainting fits, etc.) [,].

Besides the natural remedies, a sort of "psychotherapy" developed, practiced not only by Avicenna, but also for example by Arnaldus of Villa Nova (1240-1311). The latter, considered medieval Europe’s greatest physician, will be counted along with Galen and Avicenna in the inventories of physicians’ libraries throughout the Modern era [].

It is also interesting to note that in the many treatises diffused at the time (Constantine the African’s Viaticum and Pantegni, but also the Canon of Avicenna and Arnaldus of Villa Nova’s texts) women were often not described as "patients" to be cured but rather as the "cause " of a particular human disease, defined as amor heroycus or the madness of love, unfulfilled sexual desire [].

But we cannot talk about women' health in the Middle Ages without citing Trotula de Ruggiero from Salerno (11th century). While as a woman she could never become a magister, Trotula is considered the first female doctor in Christian Europe: she belonged to the ranks of famous women active in the Salerno School but discredited, among others, by Arnaldus of Villa Nova [].

Called sanatrix Salernitana, Trotula was an expert in women' diseases and disorders. Recognizing women as being more vulnerable than men, she explained how the suffering related to gynecological diseases was “intimate”: women often, out of shame, do not reveal their troubles to the doctor. Her best known work, De passionibus mulierum ante, in et post partum, deals female problems, including hysteria. Faithful to the teachings of Hippocrates, Trotula was devoted to the study of women’ diseases, of which she tried to capture the secrets, without being influenced by the prejudices and morals of her time, also giving advice on how to placate sexual desire: in her work abstinence is seen as a cause of illness and she recommends sedative remedies like musk oil or mint [].

Trotula works at a time when women are still considered inferior to men because of their physiological and anatomical differences. Hildegard of Bingen (1098-1179), German abbess and mystic, was another female doctor. Her work is very important for the attempt to reconciliate science with faith, that happens at the expense of science. Hildegard resumes the “humoral theory” of Hippocrates and attributes the origin of black bile to the original sin []. In her view, melancholy is a defect of the soul originated from Evil and the doctor must accept the incurability of this disease. Her descriptions are very interesting. Melancholic men are ugly and perverse, women slender and minute, unable to fix a thought, infertile because of a weak and fragile uterus []. In the ideology of Hildegard, Adam and Eve share responsibility with respect to original sin, and man and woman - sexually complementary - are equal in front of God and the cosmos [].

The mainstream view of the time is one in which the woman is a physically and theologically inferior being, an idea that has its roots in the Aristotelian concept of male superiority: St. Thomas Aquinas’ (1225-1274) Summa Theologica Aristotle’s assertions that “the woman is a failed man” []. The inferiority of women is considered a consequence of sin, and the solutions offered by St. Thomas’ reflection leave no doubt about what will overturn the relationship between women and Christianity: the concept of “defective creature” is just the beginning. In question 117, article 3, addressing the possibility that the human soul can change the substance, St. Thomas says that “some old women” are evil-minded; they gaze on children in a poisonous and evil way, and demons, with whom the witches enter into agreements, interacting through their eyes []. The idea of a woman-witch, which we shall call the “demonological vision”, almost becomes insuperable: preachers disclose the Old Testament’s condemnation of wizards and necromancers and the fear of witches spreads in the collective imagination of the European population. The ecclesiastical authorities try to impose celibacy and chastity on the clergy, and St. Thomas’ theological descriptions regarding woman’s inferiority are, perhaps, the start of a misogynistic crusade in the late Middle Ages.

From the thirteenth century onwards, the struggle with heresy assumes a political connotation: the Church aims tat unifying Europe under its banner, so breviaries become manuals of the Inquisition and many manifestations of mental illness are seen as obscene bonds between women and the Devil. “Hysterical” women are subjected to exorcism: the cause of their problem is found in a demonic presence. If in early Christianity, exorcism was considered a cure but not a punishment, in the late Middle Ages it becomes a punishment and hysteria is confused with sorcery [,].

Political and religious status quo in Europe is threatened by the first humanist ideas and the Church responds by intensifying inquisitions: the apogee is reached in 1484 with the Summis desiderantes affectibus, Innocent VIII’s Bull, which confirms the witch hunt and an obligation to “punish, imprison and correct” heretics [,]. The German Dominicans Heinrich “Institor” Kramer and Jacob Sprenger are accredited with the publication of the famous Hammer of Witches, the Malleus Meleficarum (1486) [,]. Although not an official Church manual, it takes on an official tone due to the inclusion of the papal Bull within the text. It is interesting to note that the title itself includes signs of misogyny: “Maleficarum” as witches, not “Maleficorum” as wizards… as if to say “evil is female/ evil origins from women”!

The devil is everywhere in these pages: he makes men sterile, kills children, causes famine and pestilence and all this with the help of witches. The compilers of the manual are familiar with the medicine of the age, and they investigate the relationship between sorcery and human temperaments: their descriptions rival those contained in the best psychopathology manuals [,]. The text is divided into three parts and aims at proving the existence of demons and witches (warning the reader that anyone not convinced is also a victim of the Devil) explaining how to find and punish sorcery.

But what has this to do with women's health? It is quite simple: if a physician cannot identify the cause of a disease, it means that it is procured by the Devil. The inquisitor finds sin in mental illness because, he says, the devil is a great expert of human nature and may interfere more effectively with a person susceptible to melancholy or hysteria. Hysteria is considered a woman's disease, and who more than women are prone to melancholy? This disease is the basis of female delirium: the woman feels persecuted and the devil himself is the cause of this “mal de vivre”, which deprives the women of confession and forgiveness, leading them to commit suicide.

Obviously, the women most affected are elderly and single, in most cases they have already been in mourning or victims of violence. Sorcery becomes the scapegoat for every calamity and etymological explanations are also provided: for Sprenger and Krämer, the Latin word foemina is formed from fe and minus, that is “who has less faith”. This text is the worst condemnation of depressive illness and women to be found throughout the course of Western history: until the eighteenth century, thousands of innocent women were put to death on the basis of “evidence” or “confessions” obtained through torture [,].

5. Renaissance

At the end of the Middleage, journeys along the coasts of the Mediterrinean sea contributed to a quick diffusion of Greek Classics, preserved and disseminated by the Arabians.

The humanistic movement (born with Dante, Boccaccio and Petrarch) emphasized a respect for the writings of the Antiquity. During these centuries, a new realistic approach to man as a person was born, which opposed the scholastics and introduced a fresh point of view about nature and man [].

Italian philosopher Giovanni Pico della Mirandola (1463-1494) espoused the principle that each man is free to determinate his own fate, a concept that perhaps more than any other has influenced the developments of the last three centuries: only man is capable of realizing his ideal and this condition can, however, be achieved only through education []. Pico’s thesis was implemented by the Spanish educator Juan Luis Vives (1492-1540). His pragmatic orientation produced occasional flashes of insight; for instance, he thought that emotional experience rather than abstract reason detained the primary role in a man’s mental processes: in order to educate a person it is necessary to understand the complex functioning of his mind [].

Up to this time the medical vision of hysteria, inherited from the Hippocratic-Galenic tradition, continues to dominate []. At the end of the 16th century, in European countries affected by the Counter-Reformation, the theological vision tends to overwhelm the medical community. During this period the most intense activity of the Roman Inquisition, in which magic has replaced the fight against heresy, is recorded. Thus in these states, a new generation of physicians emerges, which is destined to be subordinated to inquisitors []. It is precisely the physician and theologian Giovan Battista Codronchi (1547-1628) who, by criticizing the medical therapy of the time aimed at treating hysteria, give us a detailed description of them.

Codronchi said that midwives, recalling Galenus’ and Avicenna’s theachings, took care of the hysterical women introducing the fingers in their genital organs in order to stimulate orgasm and semen production []. The physician prohibited this treatment at all, an attitude due to the concern typical of that historical phase related to sex and sexual repression. The treatment for him must be practices by the spiritual guides []. And if Codronchi is also a proud supporter of the existence of demons, in favour of which he argued by referring to biblical and philosophical sources, the Italian Renaissance had already tried to condemn witch hunts and to give a “scientific” explanation of mental illness: among others, Girolamo Cardano (1501-1576) and Giovanni Battista Della Porta (1535-1615) were interested in sorcery and marginality, but did not see a demonic cause in them. They identified the origin of certain behaviors in fumes, in polluted water and in the suggestion (for Cardano) or in the acquisition of certain substances that induce “visions” and “pictures” (according to Della Porta) but both base most of their considerations on physiognomy []. Another important physician, the Dutch Johann Weyer (1515- 1588) intended to prove that witches were mentally ill and had to be treated by physicians rather than interrogated by ecclesiastics []. In 1550 he became the private physician of the Duke William of Cleves, who was a chronic depressive. The Duke observed that witches manifesedt many of the same symptoms as his relatives became insane. So, he sympathizes with Weyer’s theory that these women are really suffering from mental illness, but he cannot keep the witch hunter under control because of his transient psychotic episodes cause by an apopletic stroke []. In 1563, Weyer publishes De prestigiis Daemonum, which is a step-by-step rebuttal of the Malleus Maleficarum. He’s been called by his contemporaries “hereticus” or “insanus”, but his pages reveal that he’s not rebellious but that he’s a religious man [].

However, for the doctors of that time, the uterus is still the organ that allows to explain vulnerable physiology and psychology of women: the concept of inferiority towards men is still not outdated.

Hysteria still remains the “symbol” of femininity [].

6. Modern Age

The 16th century is a period of important medical developments, as proved by the writings of Andreas Vesalius (De humani corporis fabrica, 1543) and French surgeon Ambroise Paré (1510-1590).

These authors’ findings are the basis of the birth of modern medical science [], combined with the "philosophical revolution", in which René Descartes (1596-1650) explains how the actions attributed to the soul are actually linked with the organs of the body, and also combined with the studies on the anatomy of the brain by physician Thomas Willis (1621-1675). Willis introduces a new etiology of hysteria, no longer attached to the central role of the uterus but rather related to the brain and to the nervous system []. In 1680, another English physician, Thomas Sydenham (1624-1689), published a treatise on hysteria (Epistolary Dissertation on the Hysterical Affections) which refers back to natural history through describing an enormous range of manifestations and recognizing for the first time the fact that hysterical symptoms may simulate almost all forms of organic diseases []. However, the author fluctuates between a somatic and a psychological explanation []. Sydenham demonstrates that the uterus is not the primary cause of the disease, which he compares to hypochondria: his work is revolutionary as it opposes the prejudices, but it will take several decades for the theory of "uterine fury" to be dismissed [].

The scientific development does not mark a dramatic shift from a demonological vision of medicine, but progresses hand in hand with evolution of theories on exorcism. The written records tell us of several outbreaks of hysteria, the most famous of which is undoubtedly the one occurred in the village of Salem (Massachusetts) in 1692. The texts recall an episode in which a slave originally from Barbados talks about the prediction of fate and some girls creat a circle of initiation. This latter was formed by women yunger then twenty years of age and unmarried.The action of creating a circle of initiation was in itself an open violation of the precepts of the Puritans.

There is no record of the first stages of the disease: the girls result "possessed" since February 1692. The symptoms described were staring and barred eyes, raucous noises and muffled, uncontrolled jumps, sudden movements etc. The local doctor, William Griggs, referred the problem to the priest. The slave and two other women were summoned, and the former admitted witchcraft and pacts with the devil. Gradually they began to accuse each other. Eventually, 19 were hanged as "witches", and over 100 were kept in detention. Only when the girls accused the wife of the Colonial Governor of being part of this circle herself, the latter forbade further arrests and trials for witchcraft []. Marion Starkey, at the end of World War II, reports the case comparing it with more contemporary events []. Her explanation of classical hysteria is that the illness manifested itself in young women repressed by Puritanism, and was aggravated by the intervention of Puritan pastors, this leading to dramatic consequences. The incident proves thus that hysteria could be seen as a consequence of social conflicts [].

Social conflicts do not occur exclusively in closed societies, such as small communities such as puritanical circles, but they also occur in more open and dynamic societies asbig cities. In 1748 Joseph Raulin published a work in which he defines hysteria as an affection vaporeuse and describes it as a disease caused by foul air of big cities and unruly social life. In theory, the disorder can affect both sexes, but women are more at risk for their being lazy and irritable [].

Between the 17th and 18th centuries a trend of thought that delegated to the woman a social mission started developing. If from a moral point of view she finds redemption in maternal sacrifice that redeems the soul but it does not rehabilitate the body, from the social point of view, the woman takes a specific role. In 1775 the physician-philosopher Pierre Roussel published the treatise "Systeme physique et moral de la femme" greatly influenced by the ideas of Jean-Jacques Rousseau. Femininity is for both authors an essential nature, with defined functions, and the disease is explained by the non-fulfillment of natural desire. The excesses of civilization causes disruption in the woman as well as moral and physiological imbalance, the identified by doctors in hysteria []. The afflictions, diseases and depravity of women result from the breaking away from the normal natural functions. Following natural determinism, doctors confine the woman within the boundaries of a specific role: she is a mother and guardian of virtue []. In this context, the woman-witch appears more and more an artifice to secure the social order of ancien régime.

The Enlightenment is a time of growing rebellion against misogyny and sorcery becomes a matter for psychiatrists: in the Encyclopédie we read that sorcery is a ridiculous activity, stupidly attributed to the invocation of demons. And further: mental illness starts to to be framed within the "scientific view" and hysteria is indeed described in the Encyclopédie as one of the most complicated diseases, originally identified by ancient scientists as a problem related to the uterus. Even more interesting is the fact that the causes and symptoms of hysteria and melancholy are linked to the humor theory. Fortunately, the “demonological vision” of women's mental illness did not prevent previous medical theories from being maintained [].

The last "witch" was sentenced to death in Switzerland in 1782, 10 years after the publication of the latest volumes of the Encyclopédie. Her name was Anna Göldi, and her memory was rehabilitated only in 2008 [].

In the 18th century, hysteria starts being gradually associated with the brain rather than the uterus, a trend which opens the way to neurological etiology: if it is connected to the brain, then perhaps hysteria is not a female disease and can affect both sexes. But this is not such a simple shift as it may seem.

The German physician Franz Anton Mesmer (1734-1815) found in suggestion a method of treatment for his patients suffering from hysteria, practicing both group and individual treatments. He identified in the body a fluid called "animal magnetism" and his method soon became famous as "mesmerism". Indeed, it was thought that the magnetic action of the hands on diseased parts of the body could treat the patient, interacting with the fluid within the body. Only later we realized that this was a mere suggestion. Mesmerism had subsequent developments in the study of hypnosis [].

The French physician Philippe Pinel (1745-1826) assuming that kindness and sensitivity towards the patient are essential for good care, frees the patients detained in Paris’ Salpêtrière sanatorium from their chains. Pinel's theory derives from ideas linked to the French Revolution: “mad” is not substantially different from “healthy”, the balance is broken by the illness and treatment must retrieve this balance. Nonethelsess, Pinel too considered hysteria a female disorder [,]. Jean Martin Charcot (1825-1893) the French father of neurology, pushed for a systematic study of mental illnesses. In particular, he studied the effectiveness of hypnosis in hysteria, which, from 1870 onwards, is distinguished from other diseases of the spirit. Charcot argues that hysteria derives from a hereditary degeneration of the nervous system, namely a neurological disorder .By drawing graphs of the paroxysm, he eventually shows that this disease is in fact more common amongst men than women [-].

During the Victorian Age (1837-1901) most women carried a bottle of smelling salts in their handbag: they were inclined to swoon when their emotions were aroused, and it was believed, that, as postulated by Hipocrates, the wandering womb disliked the pungent odor and would return to its place, allowing the woman to recover her consciousness []. This is a very important point, as it shows how Hippocrates’ theories remained a point of reference for centuries.

7. Contemporary Age

French neuropsychiatrist Pierre Janet (1859-1947), with the sponsorship of J. M. Charcot, opened a laboratory in Paris’ Salpêtrière. He convinced doctors that hypnosis — based on suggestion and dissociation — was a very powerful model for investigation and therapy. He wrote that hysteria is “the result of the very idea the patient has of his accident”: the patient’s own idea of pathology is translated into a physical disability []. Hysteria is a pathology in which dissociation appears autonomously for neurotic reasons, and in such a way as to adversely disturb the individual’s everyday life. Janet studied five hysteria’s symptoms: anaesthesia, amnesia, abulia, motor control diseases and modification of character. The reason of hysteria is in the idée fixe, that is the subconscient or subconscious. For what concerns eroticism, Janet noted that “the hysterical are, in general, not any more erotic than normal person”. Janet’s studies are very important for the early theories of Freud, Breuer and Carl Jung (1875-1961) [,].

The father of psychoanalysis Sigmund Freud (1865-1939) provides a contribution that leads to the psychological theory of hysteria and the assertion of a “male hysteria”. Freud himself wrote in 1897: “After a period of good humor, I now have a crisis of unhappiness. The chief patient I am worried about today is myself. My little hysteria, which was much enhanced by work, took a step forward” []. In 1889 he published his Studies on Hysteria with Joseph Breuer (1842-1925). The key-concepts of his psychoanalytical theory (the influence of childhood sexual fantasies and the different ways of thinking of the unconscious mind) have not yet been formulated, but they are already implicit in this text. Among the cases presented, we find the hysteria of the young Katherina, who suffers from globus hystericus. The text does not refer to the famous Oedipus complex, which emerges through the study of male hysteria, developed after this treatise [-].

We now reach a crucial point: until Freud it was believed that hysteria was the consequence of the lack of conception and motherhood. Freud reverses the paradigm: hysteria is a disorder caused by a lack of libidinal evolution (setting the stage of the Oedipal conflict) and the failure of conception is the result not the cause of the deasease [-]. This means that a hysterical person is unable to live a mature relationship. Furthermore, another important point under a historical point of view is that Freud emphasizes the concept of "secondary advantage". According to psychoanalysis the hysterical symptom is the expression of the impossibility of the fulfillment of the sexual drive because of reminiscence of the Oedipal conflict [-]. The symptom is thus a "primary benefit" and allows the "discharge" of the urge - libidinal energy linked to sexual desire. It also has the "side benefit" of allowing the patient to manipulate the environment to serve his/her needs. However, it is a disease of women: it is a vision of illness linked to the mode (historically determined) to conceive the role of women. The woman has no power but "handling", trying to use the other in subtle ways to achieve hidden objectives. It is still an evolution of the concept of "possessed" woman [,].

During 19th Century, description of hysteria as a variety of bodily symptoms experiencedby a single patient is labeled Briquet’s syndrome. In 20th Century several studies are based on a particular presentation of hysteria’s symptoms: a loss or disturbance of function which does not conform to what is known about the anatomy and physiology of the body, as loss of speech but not of singing. Psychiatrists note that any function of the body can be affected by hysteria [].

An analysis of the framing of these diagnoses in British medical discourse c. 1910-1914 demonstrates that hysteria and neurasthenia, although undergoing redefinition in these years, were closely connected through the designation of both as hereditary functional diseases. Before the war these diagnoses were perceived as indicators of national decline. Continuity, as well as change, is evident in medical responses to shell-shock [].

The identification of hysterical fit, according to Pierre Janet’s theories, was for a long time considered impossible: an example of this diagnostic dilemma is provided by the Royal Free Disease, an epidemic of neurological, psychiatric and other miscellaneous symptoms which swept through the staff of the Royal Free Hospital in London between July and November 1955 and which affected a total of 292 members of staff. In the Medical Staff Report it was concluded that an infective agent was responsible []. In 1970 McEvedy and Beard put forward an alternative suggestion that Royal Free Disease was an epidemic of hysteria (for example the sensory loss affected a whole limb or part of a limb but the pattern rarely followed the distribution of nerves to the skin) and also pointed out that the spread of the symptoms, predominantly affecting young female resident staff, is characteristic of epidemics of hysteria, which usually occur in populations of segregated females such as girl schools, convents and factories. They wrote also that hysteria had a pejorative meaning in their society, but that should not prevent doctors from weighing the evidence dispassionately [].

Besides defining the nature of hysteria, 20th Century psychiatrists also considered its history and geography. During World Wars hysteria attracted the attention of military doctors, and several authors have recorded their impressions on the frequency of hysteria in this period. Under battle conditions, the way in which hysterical symptoms provide a solution for emotional conflicts is particularly clear. A soldier torn between fear of facing death and shame at being thought a coward may develop a hysterical paralysis of his arm, sickness being a legitimate way out of the conflict []. For instance, in 1919 Hurst wrote that “many cases of gross hysterical symptoms occurred in soldiers who had no family or personal history of neuroses, and who were perfectly fit”. In particular, in 1942 Hadfield commented that the most striking change in war neurosis from World War I to World War II was “the far greater proportion of anxiety states in this war, as against conversion hysteria in the last war” []. But World War II not only allowed for a comparison with World War I in terms of patterns of neurotic symptoms, but also become a opportunity for cross-cultural comparisons between troops from widely differing cultural backgrounds [].

Abse’s studies (1950) on hysteria in India during World War II demonstrate that, 57% of the 644 patients admitted to the Indian Military Hospital in Delhi during the year 1944, were diagnosed as suffering from hysteria and 12% were diagnosed as suffering from anxiety states. Abse also collected data from a British Military Hospital in Chester (June to October 1943) and he demonstrated the existence of a majority of anxiety states (50%) than hysteria cases (24%) [].

Others studies confirm these data. In particular, in 1950 Williams demonstrated that Indian hysterics were often of high morale and were of all grades of intelligence, whereas among the British, gross hysterical reactions were the breakdowns of men with low stability and morale and usually of low intelligence []. Moreover, these studies demonstrate that from World War I to World War II there was a small relative decline of hysteria among British soldiers which was paralleled by a relative rise in anxiety states and by contrast, hysteria was still the most common form of neurosis among Indian soldiers in World War II. The contrasting patterns shown by soldiers suggest that hysteria and anxiety neurosis bear a reciprocal relationship, so that the decline of the former is compensated for by a rise in the latter [].

But this also seems to demonstrate a different progress of hysterical disease in Western and non-Western societies. In the second half of the 20th century, we witness a “decrease” of hysteria (as response to stress, which represents the patient concept’s of bodily dysfunction) in western societies. Data of annual admissions for hysteria to psychiatric hospitals in England and Wales from 1949 to 1978 show that they are diminished by nearly two-thirds, with a marked decline in the proportion from 1971 onwards, and a similar decrease is recorded in a study conducted in Athens as well []. Hysteria was in fact a major form of neurotic illness in Western societies during the 19th Century and remained so up to World War II. Since then there appears to have been a rapid decline in its frequency and it has been replaced by the now common conditions of depressive and anxiety neuroses.

But the studies focused on Indian patients as well as on others non-Western countries as Sudan, Egypt and Lebanon [] demonstrate that during the second half of 20th Century hysteria, as one of the somatic ways of expressing emotional distress, remained a prominent condition among psychiatric patients, although anxiety and depressive neuroses may have gained a little ground. Hence, psychiatrists supposed that it was an unstable transitional phase and predicted the disappearance of hysteria by the end of 20th Century [].

There seems to be an inverse relationship between decreasing of hysteria and increasing of depression in Western society. The idea that depression was more likely to manifest itself in those born after the Second World War has been suggested in 1989 by Klerman []. More recently it has been documented by studies repeated over time in America and Australia, although there are exceptions in specific areas in relation to specific socio-environmental conditions and migration [-].

A systematic review of misdiagnosis of conversion symptoms and hysteria, based on studies published since 1965 on the diagnostic outcome of adults with motor and sensory symptoms unexplained by disease, demonstrate that a high rate of misdiagnosis of conversion symptoms was reported in early studies but this rate has been only 4% on average in studies of this diagnosis since 1970 []. This decline is probably due to improvements in study quality rather than improved diagnostic accuracy arising from the introduction of computed tomography of the brain [].

We know that the concept of hysterical neurosis is deleted with the 1980 DSM-III: hysterical symptoms are in fact now considered as manifestation of dissociative disorders.

The evolution of this disease seems to be a factor of the social “westernization”. Several studies on mental diseases seem to validate this hypothesis. In 1978 Henry B. Murphy (1915-1987) [] individuated the main causes of melancholy in social change and consequent socio-economic changes. A picture characterized by self-blame feelings, low self-esteem and helplessness. These features were described as being due to a rapid social change in two different social theatres: in those areas of England interested in turning the feudal economy into an industrial7at the centre of one at the end of the 17th century, and more recently in some areas of Africa affected by rapid economic development. In both cases the onset of psychopathological symptoms has been related to two main factors: on the one hand, the disruption of an enlarged family and the loss of a close emotional support for the individual, and on the other hand by a marked striving towards economic individualism. In this new psychological and external contest destiny and future will no longer be determined by fate, but menbuildtheir own destiny, an unknown and hard responsibility towards life []. In 1978 Murphy wrote that in Asia and in Africa these symptoms are rare, except among the Westernized persons, and that it could be useful to examine under what conditions these symptoms first became common in different societies [].

From the expression of discomfort "hysteria" to the expression of discomfort "melancholy" the different conception of the self isessential. The world of hysterical manifestation is a world of "dissociation": something dark (trauma, external influences) affects a symptom not directly interpretable. From here the development in the West of hypnotic therapies (up by Mesmer to Freud and Janet) [] and, in the West more than in non-Westernized world, it is the implementation of exorcism and purificatory rituals that mark the meeting with the groups: Tarantism and Argia in South Italy [], Narval-Wotal practices of West African immigrants [-]. A world linked to a vision of women as a means unaware of evil forces, "out of control" from reasonableness or (in European Positivism) be an "immature" with manipulative behavior that seeks to achieve an improper position of power. Also the world of Melancholy is female, predominantly female since women suffer from depression at a ratio of 2.5 to 1 compared to men [,]. But it is a reality in which, indeed, the patient (and therefore the patient woman) is aware of the conviction-conquest of being the master of its own destiny (and therefore to blame for their failures). We can see this passage in 1980s Africa.

Wednesday, April 8, 2020

Return of the Coronavirus: 2019-nCoV

https://www.mdpi.com/1999-4915/12/2/135/htm
[MDPI Open Access Journals]

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Journals
Viruses
Volume 12
Issue 2
10.3390/v12020135

pen AccessCommentary
Return of the Coronavirus: 2019-nCoV
by Lisa E. Gralinski 1 and Vineet D. Menachery 2,3,* [OrcID]
1
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
2
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
3
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA
*



Abstract
The emergence of a novel coronavirus (2019-nCoV) has awakened the echoes of SARS-CoV from nearly two decades ago. Yet, with technological advances and important lessons gained from previous outbreaks, perhaps the world is better equipped to deal with the most recent emergent group 2B coronavirus.
Keywords: 2019-nCoV; novel CoV; Wuhan; Wuhan pneumonia; coronavirus; emerging viruses; SARS-CoV; MERS-CoV

1. Emergence
The third zoonotic human coronavirus (CoV) of the century emerged in December 2019, with a cluster of patients with connections to Huanan South China Seafood Market in Wuhan, Hubei Province, China. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infections, patients exhibited symptoms of viral pneumonia including fever, difficulty breathing, and bilateral lung infiltration in the most severe cases [1]. News reports of patients with an unknown pneumonia were first identified on 31st December with the Wuhan Municipal Health Commission saying they were monitoring the situation closely (Figure 1). On 1st January 2020, the seafood market was closed and decontaminated while countries with travel links to Wuhan went on high alert for potential travelers with unexplained respiratory disease. After extensive speculation about a causative agent, the Chinese Center for Disease Control and Prevention (CDC) confirmed a report by the Wall Street Journal and announced identification of a novel CoV on 9th January [2]. The novel CoV (2019-nCoV) was isolated from a single patient and subsequently verified in 16 additional patients [3]. While not yet confirmed to induce the viral pneumonia, 2019-nCoV was quickly predicted as the likely causative agent.
Viruses 12 00135 g001 550

Figure 1. Timeline of the key 2019-nCoV events.

The first sequence of 2019-nCoV was posted online one day after its confirmation on behalf of Dr. Yong-Zhen Zhang and scientists at Fudan University, Shanghai [4]. Subsequently, five additional 2019-nCoV sequences were deposited on the GSAID database on 11th January from institutes across China (Chinese CDC, Wuhan Institute of Virology and Chinese Academy of Medical Sciences & Peking Union Medical College) and allowed researchers around the world to begin analyzing the new CoV [5]. By 17th January, there were 62 confirmed cases in China and importantly, three exported cases of infected travelers who were diagnosed in Thailand (2) and Japan (1) [6]. The sequences of these exported cases and several additional 2019-nCoV isolated in China have also been deposited on the GSAID database [5]. Diagnostic tests have subsequently been developed and some are being used on suspect cases identified in other locations including Vietnam, Singapore, and Hong Kong [7]. To date there have been twenty-six fatalities associated with 2019-nCoV infection, many of these cases had significant co-morbidities and were older in age (>50). A range of disease has been observed highlighted by fever, dry cough, shortness of breath, and leukopenia; patients have included mild cases needing supportive care to severe cases requiring extracorporeal membrane oxygenation; however, compared to SARS-CoV (10% mortality) and MERS-CoV (35% mortality), the 2019-nCoV appears to be less virulent at this point with the exception of the elderly and those with underlying health conditions. Initial monitoring of case close contacts had not revealed any further 2019-nCoV cases. However, modeling analysis based on official case numbers and international spread suggested that there may be cases going undetected [8]. On 19th January, these fears were seemingly confirmed as an additional 136 cases were added from further surveys raising the total in Wuhan to 198 infected patients [9]. Among the 198 total cases in Wuhan, 170 remained in hospitals, 126 mostly with mild symptoms, 35 in serious condition, and 9 in critical condition. The expanded numbers and extended range of onset dates (12 December 2019–18 January 2020) suggested likely human to human transmission or ongoing transmission from a market or other primary sources. On 20th January, the outbreak was further expanded to other parts of China (Beijing, Shanghai, & Shenzhen) as well as another exported cases to South Korea. As of January 24, the total case number has expanded to at least 870 total cases with 26 deaths across 25 provinces in China and 19 exported cases in 10 countries [10]. Public health authorities have quarantined travel from Wuhan to limit the spread of the virus and reports indicate other Chinese cities have also been isolated [11]. With the heavy travel season for lunar New Year underway in Asia, major concerns exist for the 2019-nCoV outbreak to continue and spread.

2. Origins of 2019-nCoV

The source of the 2019-nCoV is still unknown, although the initial cases have been associated with the Huanan South China Seafood Market. While many of the early patients worked in or visited the market, none of the exported cases had contact with the market, suggesting either human to human transmission or a more widespread animal source [6]. In addition to seafood, it is reported on social media that snakes, birds and other small mammals including marmots and bats were sold at the Huanan South China Seafood Market. The WHO reported that environmental samples taken from the marketplace have come back positive for the novel coronavirus, but no specific animal association has been identified [6]. An initial report suggested that snakes might be the possible source based on codon usage [12], but the assertion has been disputed by others [13]. Researchers are currently working to identify the source of 2019-nCoV including possible intermediate animal vectors.

A zoonotic reservoir harkens back to the emergence of both SARS- and MERS-CoV. SARS-CoV, the first highly pathogenic human CoV, emerged in 2002 with transmission from animals to humans occurring in wet markets. Surveillance efforts found SARS-CoV viral RNA in both palm civets and raccoon dogs sold in these wet markets [14]; however, SARS-CoV was not found in the wild, suggesting that those species served as intermediary reservoir as the virus adapted to more efficiently infect humans. Further surveillance efforts identified highly related CoVs in bat species [15]. More recent work has demonstrated that several bat CoVs are capable of infecting human cells without a need for intermediate adaptation [16,17]. Additionally, human serology data shows recognition of bat CoV proteins and indicates that low-level zoonotic transmission of SARS-like bat coronaviruses occurs outside of recognized outbreaks [18]. MERS-CoV is also a zoonotic virus with possible origins in bats [19,20], although camels are endemically infected and camel contact is frequently reported during primary MERS-CoV cases [21]. For SARS-CoV, strict quarantine and the culling of live markets in SE Asia played a major role in ending the outbreak. With the cultural importance of camels, a similar approach for MERS-CoV was not an option and periodic outbreaks continue in the Middle East. These lessons from SARS and MERS highlight the importance of rapidly finding the source for 2019-nCoV in order to stem the ongoing outbreak.

3. Susceptible Populations

With limited patient data, it is difficult to make robust declarations about populations that may be most susceptible to 2019-nCoV. However, disease severity following SARS- and MERS-CoV corresponded strongly to underlying host conditions including age, biological sex, and overall health [22]. Early patient reports from 2019-nCoV find similar trends. Severe illness with 2019-nCoV has been associated with elderly patients (>60 years old), including twenty-six lethal cases. These findings correspond to increased severity and death in people over the age of 50 following both SARS and MERS-CoV infection [23,24]. Similarly, the underlying health of the patient likely plays a critical role in overall susceptibility. For the 2019-nCoV, limited comorbidity data is available; however, the twenty-six patients that have succumbed to the novel CoV had significant health conditions including hypertension, diabetes, heart and/or kidney function issues that may have made them more susceptible. For the MERS-CoV outbreak, smoking, hypertension, diabetes, cardiovascular disease, and/or other chronic illnesses have been present in the majority of deaths and correspond to findings in animal models [25]. The results indicate vigilance is necessary for these vulnerable patients following 2019-nCoV infection.

4. Insights from the 2019-nCoV Sequence

The rapid sequencing of the nearly 30,000 nucleotide 2019-nCoV genome by Dr. Zhang’s group at Fudan University and several other groups in China illustrate the dedication and increased capacity of the scientific infrastructure in China [4,5]. For SARS-CoV, the causative agent was unknown for months and subsequently took over four weeks until a full genome was released [26]. Similarly, MERS-CoV was only identified after several months of testing and a full-length genome available about a month later [27]. In contrast, time from the first date of patient onset (12 December 2019) to the report of several 2019-nCoV full-length genomes took less than one month. Combined with the immense pressure of an ongoing outbreak with an unknown agent, the effort of these scientists should be considered nothing less than remarkable.
Building from the sequence, the nucleotide alignment quickly distinguished the novel virus as a group 2B CoV, distinct from the SARS-CoV strains [4,5]. Examining the whole genome, 2019-nCoV maintains ~80% nucleotide identity to the original SARS epidemic viruses. Its closest whole genome relatives are two bat SARS-like CoVs (ZC45 and ZXC21) that shared ~89% sequence identity with 2019-nCoV; these CoV sequences were deposited in early 2018 from Zhejiang province in R. sinicus bats in China. Comparing across the deposited 2019-nCoV strains finds > 99.5% conservation; the lack of diversity suggests a common lineage and source with emergence not likely having occurred that long ago [28,29]. A recent report has subsequently identified a bat CoV sequence, RaTG3, with 92% sequence identity with the novel virus which argues for bat origins for the 2019-nCoV [30].

We next shifted analysis to the nucleocapsid (N) protein, the most abundant protein produced in CoVs. Generally, the N protein is well conserved across CoV families including group 2B [31]. The N protein for 2019-nCoV is no exception with ~90% amino acid identity to the SARS-CoV N protein. While less conserved than other group 2B CoVs like HKU3-CoV and SHC014-CoV, 2019-nCoV antibodies against the N protein would likely recognize and bind the SARS-CoV N protein as well. N antibodies do not provide immunity to 2019-nCoV infection, but the cross reactivity with SARS-CoV N protein would allow a serum based assay to determine exposure to the novel CoV in asymptomatic cases. While previous studies have found serum reactivity to group 2B virus N proteins in Chinese populations [18], exposure to 2019-nCoV should increase the dilution factor substantially if exposure/infection had occurred. Importantly, this information may provide insights about susceptibly and potential routes of spread through asymptomatic carriers.
Examining further, we next compared the spike proteins, the critical glycoprotein responsible for virus binding and entry. Overall, the 2019-nCoV spike protein has roughly 75% amino acid identity with SARS-CoV, which is less conserved than other group 2B CoVs including HKU3-CoV [31]. However, narrowing analysis to the spike receptor binding domain (RBD) of SARS-CoV (amino acids 318–518), the 2019-nCoV RBD is 73% conserved relative to the epidemic RBD. This conservation level places the 2019-nCoV RBD between HKU3-4 (62.7% conservation), a bat virus that cannot use human ACE2, and rSHC014 (80.8%), the most divergent bat CoV spike known to use human ACE2 for entry [16,32]. Importantly, the key binding residues for SARS-CoV have been identified [33]; among these fourteen residues predicted to interact directly with human ACE2, the receptor for SARS-CoV, eight amino acids are conserved in 2019-nCoV. Notably, several of these residues are also conserved relative to WIV1- and WIV16-CoV, two bat strains closely related to SARS-CoV and known to use human ACE2 [17,34]. Initial structural modeling suggest that the 2019-nCoV may be able to use human ACE2 as a receptor, although its affinity m be reduced relative to the epidemic SARS-CoV strains [35]. A subsequent report demonstrated that the receptor binding domain of 2019-nCoV was capable of binding ACE2 in the context of the SARS-CoV spike protein [36]. In addition, another rapid report links demonstrates 2019-nCoV uses ACE2 receptors from human, bat, civets, and swine [30]. Together, the modeling, pseudotyping, and infection data provide strong evidence for human ACE2 being the receptor for 2019-nCoV.

5. Achieving Koch Postulates

Traditional identification of a microbe as the causative agent of disease requires fulfillment of Koch’s postulates, modified by Rivers for viral diseases [37]. At the present time, the 2019-nCoV has been isolated from patients, detected by specific assays in patients, and cultured in host cells (one available sequence is identified as a passage isolate), starting to fulfill these criteria. Given the recentness of the 2019-nCoV outbreak, at this point there is no animal model available to fulfill the remaining criteria: 1) testing the capability of 2019-nCoV to cause respiratory disease in a related species, 2) re-isolating the virus from the experimentally infected animal and 3) detection of a specific immune response. These efforts will surely be an area of intense research in the coming months both in China and in CoV research laboratories around the world.
Notably, generating small animal models of coronavirus disease can be difficult. While SARS-CoV readily infected laboratory mice, it does not cause significant disease unless the virus is passaged to adapt to the mouse host [38]. Infection of primates produces a more mild disease than that observed in humans, although fever and pulmonary inflammation were noted [39,40]. MERS-CoV is incapable of infecting rodent cells without engineering changes in critical residues of the receptor protein, DPP4 [41,42]. However, MERS-CoV does infect non-human primates [43]. As such, MERS mouse models of disease required a great deal of time to develop and are limited in the types of manipulations that can be performed [41]. At this point, the infectious capability of the 2019-nCoV for different species and different cell types is unknown. Early reports suggest that the virus can utilize human, bat, swine, and civet ACE2 [30]; notably, the group found mouse Ace2 was not permissive for 2019-nCoV infection Dissemination of virus stocks and/or de novo generation of the virus through reverse genetics systems will enable this research allowing for animal testing and subsequent completion of Koch’s postulates for the new virus.

6. Threat for Spread: Human to Human, Health Care Workers, and Super Spreaders

While the Huanan seafood market in Wuhan has been associated with the majority of cases, many of the recent cases do not have a direct connection [9]. This fact suggests a secondary source of infection, either human to human transmission or possibly infected animals in another market in Wuhan. Both possibilities represent major concerns and indicate the outbreak has the potential to expand rapidly. For human to human transmission, there was limited data in the initial set of cases; one family cluster is of three men who all work in the market. Similarly, a husband and wife are among the patients, with the wife claiming no contact with the market. In these cases, direct human to human infection may have been possible; alternatively, a contaminated fomite from the market may also be responsible as surfaces all around the market were found to test positive 2019-nCoV. However, the major increase in the number of cases, the lack of direct connection to the Wuhan market for many cases, and the infection of health care works all suggest human to human spread is likely [9,44]. Importantly, until the source of the virus is found, it will be difficult to distinguish zoonotic versus human to human spread.

In the early part of the outbreak, the absence of infection in health care workers argued for inefficient human to human spread and distinguished 2019-nCoV from both SARS-CoV and MERS-CoV. In the two prior CoV epidemics, health care settings served as a major transmission point fueling both outbreaks. Based on WHO data, 1 in 10 MERS-CoV cases have been found to be health care workers; these patients generally have reduced disease and death likely due to younger age and absence of existing health conditions. The recent reports of numerous infected health care workers in Wuhan indicate human to human infection can occur with 2019-nCoV and may be the product of a super spreading patient [44]. However, while large swaths of healthcare workers are not getting sick as seen with SARS and MERS-CoV, it may be too early to rule out their potential exposure to the novel CoV as their disease may be asymptomatic. While not described during the SARS-CoV outbreak, asymptomatic cases ranged from 12.5% to 25% in some MERS-CoV studies [45]. A similar phenomenon may be occurring with 2019-nCoV and would make stopping the outbreak even more difficult to contain.

Another parameter to consider is the possibility of super spreading in the context of 2019-nCoV. Super spreading is the amplified transmission of a virus by individuals in a population and has been suggested by at least one news report [44]. Both SARS- and MERS-CoV outbreaks had documented evidence of super spreading patients [46]. In general, both epidemic CoVs maintain a low R0, the rate spread from an individual infected patient. However, roughly 10% of SARS- and MERS-CoV patients have been associated with super spreading and an R0 > 10. These cases seeded a significant portion of the epidemic around the world. Notably, neither mutations in the viruses nor severity of disease were found to be associated with super spreading, implying that host factors contribute to the phenotype [47]. For 2019-nCoV, contact tracing to date suggest limited human to human spread and a low R0. However, the recent increase in cases, both in and outside Wuhan could signal the existence of super-spreading individuals fueling the outbreak. Alternatively, super spreading could occur from the zoonotic source which has been seen in other disease outbreaks [10]. In any event, the possibility of super spreading may continue to play a role in this ongoing 2019-nCoV outbreak.

7. Emerging Diseases in the Age of Social Media

News of the 2019-nCoV came to widespread attention through the internet. Over the years, websites like FluTrackers.com, ProMED (promedmail.org), and others have permitted the collection of disease information from around the world and facilitated dissemination to interested parties. In 2012, MERS-CoV first drew attention as a “novel coronavirus” entioned on ProMED Mail and subsequently through conversation on twitter between science journalists, virologists, and public health experts. Eight years later, a more connected network quickly dissected statements from the Wuhan Municipal Health Commission and speculated about possible causes. Early during an outbreak, it can be difficult to distinguish between rumors with elements of truth versus baseless fear mongering. This fact can be exacerbated by language barriers and off the record sources. However, in this case, speculation of a novel coronavirus was fed by carefully worded statements that specifically excluding some virus families (influenza, adenovirus), but only excluded SARS-CoV and MERS-CoV for coronaviruses. Coupled with memories of the SARS outbreak, many worried that the truth may be held back. When the agent was finally confirmed as a CoV, the world acted with both worry and relief: the outbreak would not be hidden.

While far from perfect, the government response to 2019-nCoV provides a stark contrast to the SARS outbreak at the beginning of the century. The rapid release of 2019-nCoV sequences permitted the research community to quickly become engaged, providing analysis and developing diagnostic tests. Both the Chinese CDC and the Wuhan Municipal Health Commission have posted regular updates of confirmed case numbers and patient statuses enabling public health authorities to monitor the situation in real time. Researchers from around the world have connected on social media to compare updated sequence information and highlight key unknowns about the outbreak. While not always provided in a timely manner, the ability to share news updates and data in real time with researchers and public health officials around the world signals a major change in the response to outbreaks. This connectivity has facilitated awareness as well as new collaborations and a rapid response by the global research community. While there are many unknowns with 2019-nCoV, the world is engaged and prepared to battle the newest emergent virus strain. Perhaps this means the lessons from the SARS outbreak have truly been learned.
Author Contributions

L.E.G. and V.D.M. prepared this manuscript. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Conflicts of Interest
The authors declare no conflict of interest.
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Friday, March 3, 2017

Ronald Reagan Mental Hospitals and Sick gets Sicker


 I'm having some trouble discerning what planet you may come from where hypocrisy is something to be heralded... Seriously, you do, in this posting, provide some measure of truth to what specific forms of neglect, abuse, and mistreatment many patients and inmates did, truly experience! But, you lie like a wanton whore about the very abuse that was reported to have taken place; it REALLY did take place!!

 "After the turn of the century, state hospitals became warehouses for an increasing number of people who society deemed undesirable, including criminals, the poor, homosexuals, those with unorthodox religious views, unwanted children, the elderly, syphilitics, alcoholics and anyone else who was inconvenient to those around them. During this period, it was frighteningly easy to commit a wife who was no longer wanted, children who misbehaved or aging parents whose care was too cumbersome." "The care for patients also became unimaginably nightmarish: there were wards full of malnourished, unclothed and filthy patients, who were forced to eat rotten food and sleep in quarters that were falling apart, often fatally exposing them to the elements. With staffing ratios at unthinkable levels (at times 1 staff member to 200 patients) and facilities crammed to nearly double their intended capacities, abuse by staff also became incredibly problematic. Patients were severely beaten, raped, prostituted, denied medical care and otherwise mistreated to levels that are beyond comprehension. One cannot help but think when looking at pictures from this period that the patients are nearly indistinguishable from Holocaust survivors." "There is simply no way to encompass all the cruelties heaped on the patients; most are familiar with lobotomies, which gained popularity as they produced manageable patients, albeit those whose cognitive functioning had been permanently impaired. A particularly barbaric variation of this treatment was performed at Athens State Hospital by Dr. Walter Freeman (1895-1972), who made use of neither anesthetics nor an operating room, and whose careless technique shocked even other doctors and nurses familiar with the procedure. Another common form of treatment was hydrotherapy in which a patient was placed in a tub, which would be filled with either scalding or freezing water, and a sheet was zipped around the neck so only the head was sticking out. Depending on the temperament of the staff, the patient might be left in such a state for days without even a pause to use the bathroom. As the hospitals' intent was less to cure than to warehouse patients, the purpose of the treatments was less to produce any measurable improvement in their condition than to subdue them, making them convenient for the staff." Hmm, I think I smell a hypocrite! Reply to this post

: Re: PLAGIARIST "Matthew Murray" Here is HIS "SOURCE!"

 The rise and fall of state hospital State school was dumping ground Robert Mielke, shown here during a stroll around the grounds of the Northampton State Hospital, said he struggled when patients occasionally asked why they were hospitalized. "Today, I'd probably have an answer," he says. Mielke worked in many different jobs at the now-closed hospital



Reaching the end of a pitted, weed-choked driveway of the Northampton State Hospital, Robert Mielke said that when patients sometimes asked why they were hospitalized, he had no answer to give them. He turned a deaf ear to the question, he said, because in many cases there was no good reason for their confinement. During the many years he worked at the now-closed hospital - first as a groundskeeper, then on the wards, and eventually as hospital treasurer - he didn't have the answer he has now: that thousands of patients filled the wards, grew old and, in some cases, died at the hospital simply because society was not able or willing to care for them in any other way. In its heyday, the hospital was a town within a town, he said, as he stood near the edge of the sun-dappled campus on a September morning. 

It took more than an hour for Mielke to amble around the silent buildings overlooking Northampton. He pointed out the overgrown peach and apple orchards, the site of the greenhouses, the dormitories for married couples, and the doors to the honeycomb of tunnels under the property. The significance of the decaying structure, now silent but for the occasional wind-slammed door and the shriek of rusty air vents, is as sprawling as the hospital itself. Its legacy, Mielke said, is imprinted upon every patient who passed through the hospital doors and, sometimes, asked why they were there. "How do you answer people who ask 'why am I are here?' 

What do you say?" said Mielke, now 53. "Today, I'd probably have an answer." The boom, the bust More than a century ago, Northampton State Hospital was in the forefront of reform efforts to improve conditions for people with mental illness.

 The hospital and its nearby sister institution, the Belchertown State School, boomed together, becoming integral parts of the area economy by mid-century. Eventually, they also became emblems of the way society segregated the ill, the disabled and the outcast. As medicine and technology advanced, and attitudes about mental illness and retardation slowly shifted, both area institutions were caught in a tide of social change that swept the nation in the 1960s and 1970s

. This interior photograph was taken in 1985, after this building at the Northampton State Hospital was emptied. Gazette File Photo Those changes focused on emptying such places rather than filling them, and discharging people with mental illness and retardation into community settings. The state shifted care to a new generation of reformers in the private sector, and boarded up the buildings at both institutions for eventual sale and development. 

The evidence of those changes are visible everyday in Northampton, Belchertown, and the surrounding towns. Most care for people with mental illness and mental retardation has shifted from hospitals and institutions to private organizations founded upon a vision of treating these people in the community, as equals. These agencies and advocacy organizations, with unlocked doors that open onto neighborhood streets and downtown hubs, strive to integrate people with mental illness and retardation into the fabric of society - rather than banish them to society's margins. Good intentions Though Northampton State Hospital and Belchertown State School eventually came to represent much of what could go wrong with care for mentally ill and retarded people, they initially were viewed as humane alternatives to inhumane conditions. 


In 1841, a young Boston school teacher named Dorothy Dix began teaching religion to jail inmates at Middlesex County Jail. To her shock, she discovered a "mad woman" chained to the wall in a basement cell. Dix gave up teaching and began investigating the plight of people with mental illness and mental retardation across the commonwealth. In 1843, she reported the findings of her town-by-town investigation to the Legislature. People with mental illness and retardation were confined in cells and cages in nearly every community in the state, "chained, naked, beaten with rods, and lashed into obedience," she told lawmakers. Responding to Dix's stinging report, the state began funding institutions to care for the people Dix found, differentiating for the first time between mental illness and mental retardation. The state's only hospital for the mentally ill in Worcestor, built in the 1830s, had became overcrowded, and so the state funded new hospitals for the mentally ill in Northampton and Taunton. 

The Northampton Lunatic Hospital opened in 1858 around the notion that "moral treatment" of fresh air, hard work and regimented schedules for people with mental illness would cure them, according to "The Life and Death of Northampton State Hospital," a book published by Historic Northampton. A publication of the time summed up that optimism. The Ballou's Pictorial Drawing Room Companion proclaimed in 1956 that the hospital was "an exponent of the humane feeling that is entering the state government, replacing the cold and unChristian-like spirit which has formerly regarded these poor, unfortunate beings." Those attitudes, in turn, evolved. Pliny Earle, hospital superintendent from 1864 to 1885, was once an advocate of such "moral treatment," but by the time he arrived in Northampton, he had come to doubt whether it could cure mental illness, and he began to emphasize work rehabilitation for the patients.

 By the close of the 18th century, Northampton State Hospital - as it was renamed - had became a place not to cure, but to warehouse poor people who could not afford psychiatric care, as well as the senile, the elderly and others who, by today's medical standards, were not mentally ill at all. There were about 600 patients at the hospital at the turn of the century; by the 1950s, that number would increase four-fold, to almost 2,500. The hospital's heydey When the hospital reached its peak census in 1955, it was a booming enterprise that provided some of the region's best-paying, most stable jobs. It had also become a nearly self-sufficient entity, boasting its own gardens, slaughter houses and canneries. Entire families of employees lived on or near the campus. There were baseball teams and social events, and constant traffic down the hill from the hospital to the town. Shirley Gallup came to Northampton from South Carolina in 1958, when there were more than 2,200 patients. She expected that her new job as a psychiatrist for newly admitted women would last one or two years, she said. She stayed for 28. When Gallup arrived, the hospital was bulging at the seams, a small city on a hill above Northampton - and already ripe for reform. 

By that time, the hospital was overcrowded, underfunded and physically declining. It would be years later before any legal protections would exist to prevent people from being involuntarily committed. The living evidence of that legal void was in the hospital's back wards and infirmaries. The hospital had many patients with genuine mental illness. But it also housed many people with temporary conditions, such as mothers with post-partum depression, and other who were simply old, unable to speak English, physically disabled, deaf, rebellious, or sexually promiscuous.

 "I felt, as I saw the patients, that some didn't need to be in the hospital. Some needed to be in nursing homes. Six hundred of those 2,300 were geriatric," said Gallup. "The older ones - they didn't have the family to take care of them. They aged there, and they didn't know anything but institutional life." It was around this time that two key factors emerged: anti-psychotic medications that could control depression and psychosis, and a movement to legally redefine how patients could be committed to hospitals and what rights to treatment they had. It was in the early 1960s that "deinstitutionalization" efforts began in earnest, pushed by mandates from President Kennedy on the federal level. During those years, most of the patients left the hospital, and the town began to see more of its neighbors from the hill, according to Robert Fleischner, staff attorney at the Center for Popular Representation, the Northampton legal group that advocated on behalf of patients. "By the time of deinstitutionalization, Northampton had a high level of tolerance and was used to seeing people downtown," said Fleischner. "That's not to say that it was perfect - it wasn't.

 But there was a willingness to have people around who look different and act differently." Making the case for change By the 1970s, the anti-institution movement among parents of children with mental illness and retardation was swiftly gaining ground.

 It was fueled by media reports such as the 1970 "Tragedy of Belchertown" series in the Union-News of Springfield and the expose of Willowbrook Hospital in New York State.

 Two short years later, the Belchertown School Friends Association, spearheaded by Amherst parent Benjamin Ricci, filed a lawsuit against the state, seeking to improve conditions at Belchertown State School. 

By 1976, the patient census at the Northampton State Hospital had fallen sharply, to 536. But the pace of change was not fast enough for legal advocates of the mentally ill. Documenting patients' behavior on the wards, they came to believe that patients who could easily live healthy, productive lives had assumed "institutional behaviors" that made them appear sicker than they were. In other words, the hospital was not curing patients, but making their conditions worse, according to Fleischner.

 Taking a page from the Belchertown School Friends Association suit and other groups like it, the lawyers who later formed the Center for Public Representation filed a class-action suit in 1976 on behalf of a state hospital patient named David Brewster and others there. Two years later, that lawsuit against the commonwealth of Massachusetts would be settled in what became known as the Brewster Consent Decree.

 That agreement, overseen by U.S. District Court officials, promised to reduce the hospital census to about 50 patients and to discharge the rest into the community, according to Fleischner. "It was revolutionary to think of putting people into group homes of eight or nine people," said Fleischner. Raymond P. Brien,regional director of the Department of Mental Health from 1976 to 1979, said those years were "very emotional" for everyone involved. Because he has a sister with mental retardation, he entered the social work field in the 1960s - just ahead of the regional and nationwide sea change in attitudes. "On both the mental retardation and mental health side, I got to know people who were pioneers who had profound beliefs that most of the people in those institutions didn't need to be there," said Brien.

 "It was the first region in the country that closed both its state hospital and the state school without dumping the patients." Dr. Jeffrey Geller served as medical director of the state hospital from 1979 until 1984. He helped draft the the lawsuit, and then joined the hospital staff the year after the consent decree to help implement it. Even today, some people involved with the hospital believe that the need remains for inpatient hospitals to treat mental illness, and Mielke and Geller are among them. Though Geller's view has shifted since that time, he felt a "tremendous excitement" in the aftermath of the decree, he said. The original timeline for the decree's implementation was set for 2 ½ years. Instead, it took 15, and ended in a conclusion that even Brewster's lawyers had not originally foreseen: The state opted to close the hospital completely. On Aug. 26, 1993, Northampton State Hospital discharged its last 11 patients, and, with the van door slammed behind the ex-patients, Northampton's hospital for the mentally ill became a piece of history. Early questions Not everyone shared the enthusiasm for deinstitutionalization.

 In the early 1980s, as new community programs opened and spread in Northampton, some residents - including then-Mayor David Musante - feared that Northampton was becoming a "mental health ghetto," as one prominent piece of graffiti in downtown Northampton proclaimed at the time. Several incidents involving former patients, including fires set at halfway houses, reinforced that impression and led to efforts to rein in the spread of group homes.

 Rebecca Macauley was one of those who sought to confront fear about deinstitutionalization. Even today, she has constant reminders of her past: Out the kitchen window of Macauley's Old South Street house, through a dip in the tree line, she can see a copper-domed spire atop Building G, a hospital ward where she was once a patient. Macauley said that for years, people associated with the hospital carried "anti-resumes" they only shared among themselves - lists of all the places they were hospitalized, all the treatments they received, the experiences they endured. The anti-resume she accumulated after the death of her husband included five hospitalizations at Northampton and five at the Department of Veterans Affairs Medical Center in Leeds.

 Macauley said that during the early 1980s, there was a "terrible stigma" associated with being a hospital patient. She eventually "came out" in a letter to the Gazette, saying there was a "witch hunt" afoot in Northampton that sought to blame the mentally ill for all of the city's problems. She got into a public exchange with Musante in the newspaper's pages, and eventually arrived in his office unannounced for an angry showdown. Instead, the two became fast friends - an example, she said, of the healing that can, and must, take place in the long shadow the hospital casts over Northampton. "It was great, we had a great conversation. We became good friends after that. I knew what he was saying, I knew what those fears were," said Macauley. "Northampton State Hospital is an example of failed social policy. It seemed like a good idea at the time, but no one looked far enough down the road to see what it would become. And now, we're living with that legacy."